NEET MDS Lessons
Anatomy
The Pharynx
- The pharynx is the continuation of the digestive system from the oral cavity.
- It is a funnel-shaped fibromuscular tube that is the common route for both food and air.
- The pharynx is located posterior to the nasal and oral cavities, and the larynx.
- For the convenience of description, the pharynx is divided into three parts: (1) the nasopharynx, posterior to the nose and superior to the soft palate; (2) the oropharynx, posterior to the mouth; and (3) the laryngopharynx, posterior to the larynx.
- The pharynx is about 15 cm long.
- It extends from the base of the skull to the inferior border of the cricoid cartilage anteriorly, and to the inferior border of C6 vertebra posteriorly.
- It is widest (about 5 cm) opposite the hyoid bone and narrowest (about 1.5) at its inferior end, where it is continuous with the oesophagus.
- The posterior wall of the pharynx lies against the prevertebral fascia, with the potential retropharyngeal space between them.
Superior Constrictor Muscle
- Origin: Hamulus, pterygo-mandibular raphe, and mylohyoid line of the mandible.
- Insertion: Median raphe of the pharynx.
- Nerve Supply: Vagus nerve via the pharyngeal plexus.
- Arterial Supply: Ascending pharyngeal artery, ascending palatine artery, tonsillar branch of the facial artery, and dorsal branch of the lingual artery.
- Action: Constricts the wall of the pharynx during swallowing.
Initially, four clefts exist; however, only one gives rise to a definite structure in adults.
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1st pharyngeal cleft |
Penetrates underlying mesenchyme and forms EAM. The bottom of EAM forms lateral aspect of tympanic cavity. |
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2nd pharyngeal cleft |
Undergoes active proliferation and overlaps remaining clefts. It merges with ectoderm of lower neck such that the remaining clefts lose contact with outside. Temporarily, the clefts form an ectodermally lined cavity, the cervical sinus, but this disappears during development. |
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| Motor Innervation | All muscles by hypoglossal nerve (CN XII) except palatoglossus muscle (by the pharyngeal plexus) | ||
| General Sensory Innervation |
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| Special Sensory Innervation |
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Muscles Around the Mouth
- The sphincter of the mouth is orbicularis oris and the dilator muscles radiate outward from the lips like the spokes of a wheel.
Orbicularis Oris Muscle
- This muscle encircles the mouth and is the sphincter of the oral aperture
- This muscle (1) closes the lips, (2) protrudes them and (3) compresses them against the teeth.
- It plays an important role in articulation and mastication. Together with the buccinator muscle, it helps to hold the food between the teeth during mastication.
Zygomaticus Major Muscle
- It extends from the zygomatic bone to the angle of the mouth.
- It draws the corner of the moth superolaterally during smiling and laughing.
Zygomaticus Minor Muscle
- This is a narrow slip of muscle, and passes obliquely from the zygomatic bone to the orbicularis oris.
- It helps raise the upper lip when showing contempt or to deepen the nasolabial sulcus when showing sadness.
The Buccinator Muscle
- This is a thin, flat, rectangular muscle.
- It is attached laterally to the alveolar processes of the maxilla and mandible, opposite the molar teeth and the pterygomandibular raphe.
- Medially, its fibres mingle with those of orbicularis oris.Innervation: the buccal branch of facial.
- It aids mastication and swallowing by pushing the cheeks against the molar teeth during chewing.
Eye
At week 4, two depressions are evident on each of the forebrain hemispheres. As the anterior neural fold closes, the optic pits elongate to form the optic vesicles. The optic vesicles remain connected to the forebrain by optic stalks.
The invagination of the optic vesicles forms a bilayered optic cup. The bilayered cup becomes the dual layered retina (neural and pigmented layer)
Surface ectoderm forms the lens placode, which invaginates with the optic cup.
The optic stalk is deficient ventrally to contain choroids fissure to allow blood vessels into the eye (hyaloid artery). The artery feeds the growing lens, but will its distal portion will eventually degenerate such that the adult lens receives no hyaloid vasculature.
At the 7th week, the choroids fissure closes and walls fuse as the retinal nerve get bigger.
The anterior rim of the optic vesicles forms the retina and iris. The iris is an outgrowth of the distal edge of the retina.
Optic vesicles induces/maintains the development of the lens vesicle, which forms the definitive lens. Following separation of the lens vesicle from the surface ectoderm, the cornea develops in the anterior 1/5th of the eye.
The lens and retina are surrounded by mesenchyme which forms a tough connective tissue, the sclera, that is continuous with the dura mater around the optic nerve.
Iridopupillary membrane forms to separate the anterior and posterior chambers of the eye. The membrane breaks down to allow for the pupil
Mesenchyme surrounding the forming eye forms musculature (ciliary muscles and pupillary muscles – from somitomeres 1 and 2; innervated by CN III), supportive connective tissue elements and vasculature.
Eyelids
Formed by an outgrowth of ectoderm that is fused at its midline in the 2nd trimester, but later reopen.
Skeletal Muscle: 1-40 cm long fibres, 10- 60 µm thick, according to myoglobin content there are:
Red fibres: lots of myoglobin, many mitochondriam slow twitching - tire slowly
White fibres: less myoglobin, less mitochondria, fast twitching - tire quickly
Intermediate fibres:
mixture of 2 above
Most muscles have all three - in varying ratios
Structure of skeletal muscle:
Light Microscopy: Many nuclei - 35/mm, Nuclei are oval - situated peripheral, Dark and light bands
Electron Microscopy: Two types of myofilaments
Actin
- 5,6 nm
3 components:
-actin monomers,
-tropomyosin - 7 actin molecules long
- troponin
actin monomers form 2 threats that spiral
- tropomyosin - lie in the groove of the spiral
- troponin - attach every 40 nm
- one end attach to the Z line
- other end goes to the middle of the sarcomere
- Z line consists of á actinin
Myosin:
- 15 nm
- 1,6 µm long
- The molecule has a head and a tail
- tails are parallel
- heads project in a spiral
- in the middle is a thickening
- thin threats bind the myosin at thickening (M line)
Contraction:
A - band stays the same, I - band, H - bands become narrower
Myosin heads ratchet on the actin molecule
Sarcolemma: 9 nm thick, invaginate to form T-tubule,
myofibrils - attach to the sarcolemma
Sarcoplasmic Reticulum:
specialized smooth EPR, Consists of T-tubules, terminal sisternae and sarcotubules
It is speculated that there are gap junctions between the T-tubule and terminal sisterna
An impulse is carried into the fiber by the T-tubule from where it goes to the rest of the sarcoplasmic reticulum
Connective tissue coverings of the muscle
Endomycium around fibres, perimycium around bundles and epimycium around the whole muscle
Blood vessels and nerves in CT
CT goes over into tendon or aponeurosis which attaches to the periosteum
Nerves:
The axon of a motor neuron branches and ends in motor end plates on the fiber
Specialized striated fibres called spindles (stretch receptors) form sensory receptors in muscles telling the brain how far the muscle has stretched