Extrinsic Muscles of the Tongue (p. 746)

The Genioglossus Muscle

• This is a bulky, fan-shaped muscle that contributes to most of the bulk of the tongue.
• It arises from a short tendon from the genial tubercle (mental spine) of the mandible.
• It fans out as it enters the tongue inferiorly and its fibres attach to the entire dorsum of the tongue.
• Its most inferior fibres insert into the body of the hyoid bone.
• The genioglossus muscle depresses the tongue and its posterior part protrudes it.

The Hyoglossus Muscle

• This is a thin, quadrilateral muscle.
• It arises from the body and greater horn of the hyoid bone and passes superoanteriorly to insert into the side and inferior aspect of the tongue.
• It depresses the tongue, pulling its sides inferiorly; it also aids in retrusion of the tongue.

The Styloglossus Muscle

• This small, short muscle arises from the anterior border of the styloid process near its tip and from the stylohyoid ligament.
• It passes inferoanteriorly to insert into the side and inferior aspect of the tongue.
• The styloglossus retrudes the tongue and curls its sides to create a trough during swallowing.

The Palatoglossus Muscle 

• Superior attachment: palatine aponeurosis.
• Inferior attachment: side of tongue.
• Innervation: cranial part of accessory nerve (CN XI) through the pharyngeal branch of vagus (CN X) via the pharyngeal plexus.

• This muscle, covered by mucous membrane, forms the palatoglossal arch.

• The palatoglossus elevates the posterior part of the tongue and draws the soft palate inferiorly onto the tongue.

Eye 

At week 4, two depressions are evident on each of the forebrain hemispheres.  As the anterior neural fold closes, the optic pits elongate to form the optic vesicles.  The optic vesicles remain connected to the forebrain by optic stalks. 
The invagination of the optic vesicles forms a bilayered optic cup.  The bilayered cup becomes the dual layered retina (neural and pigmented layer)
Surface ectoderm forms the lens placode, which invaginates with the optic cup.
The optic stalk is deficient ventrally to contain choroids fissure to allow blood vessels into the eye (hyaloid artery).  The artery feeds the growing lens, but will its distal portion will eventually degenerate such that the adult lens receives no hyaloid vasculature.
At the 7th week, the choroids fissure closes and walls fuse as the retinal nerve get bigger.
The anterior rim of the optic vesicles forms the retina and iris.  The iris is an outgrowth of the distal edge of the retina.
Optic vesicles induces/maintains the development of the lens vesicle, which forms the definitive lens.  Following separation of the lens vesicle from the surface ectoderm, the cornea develops in the anterior 1/5th of the eye.
The lens and retina are surrounded by mesenchyme which forms a tough connective tissue, the sclera, that is continuous with the dura mater around the optic nerve.  
Iridopupillary membrane forms to separate the anterior and posterior chambers of the eye.  The membrane breaks down to allow for the pupil
Mesenchyme surrounding the forming eye forms musculature (ciliary muscles and pupillary muscles – from somitomeres 1 and 2; innervated by CN III), supportive connective tissue elements and vasculature.

Eyelids

Formed by an outgrowth of ectoderm that is fused at its midline in the 2nd trimester, but later reopen.

Muscles of the Pharynx

• This consists of three constrictor muscles and three muscles that descend from the styloid process, the cartilaginous part of the auditory tube and the soft palate.

External Muscles of the Pharynx 

• The paired superior, middle, and inferior constrictor muscles form the external circular part of the muscular layer of the wall.
• These muscles overlap each other and are arranged so that the superior one is innermost and the inferior one is outermost.

• These muscles contract involuntarily in a way that results in contraction taking place sequentially from the superior to inferior end of the pharynx.
• This action propels food into the oesophagus.

• All three constrictors of the pharynx are supplied by the pharyngeal plexus of nerves, which lies on the lateral wall of the pharynx, mainly on the middle constrictor of the pharynx.
• This plexus is formed by pharyngeal branches of the glossopharyngeal (CN IX) and vagus (CN X) nerves.

The Superior Constrictor Muscle

• Origin: pterygoid hamulus, pterygomandibular raphe, posterior end of the mylohyoid line of the mandible, and side of tongue.
• Insertion: median raphe of pharynx and pharyngeal tubercle.
• Innervation: though the pharyngeal plexus of nerves.

• The pterygomandibular raphe is the fibrous line of junction between the buccinator and superior constrictor muscles.

The Middle Constrictor Muscle

• Origin: stylohyoid ligament and greater and lesser horns of hyoid bone.
• Insertion: median raphe of pharynx.
• Innervation: through the pharyngeal plexus of nerves.

The Inferior Constrictor Muscle

• Origin: oblique line of thyroid cartilage and side of cricoid cartilage.
• Insertion: median raphe of pharynx.
• Innervation: through the pharyngeal plexus of nerves.

• The fibres arising from the cricoid cartilage are believed to act as a sphincter, preventing air from entering the oesophagus. 

Gaps in the Pharyngeal Musculature

• The overlapping arrangement of the three constrictor muscles leaves 4 deficiencies or gaps in the pharyngeal musculature.
• Various structures enter and leave the pharynx through these gaps.

• Superior to the superior constrictor muscle, the levator veli palatini muscle, the auditory tube, and the ascending palatine artery pass through a gap between the superior constrictor muscle and the skull.
• Superior to the superior border of the superior constrictor, the pharyngobasilar fascia blends with the buccopharyngeal fascia to form, with the mucous membrane, the thin wall of the pharyngeal recess.

• Between the superior and middle constrictor muscles, the gateway to the mouth, though which pass the stylopharyngeus muscle, the glossopharyngeal nerve (CN IX), and the stylohyoid ligament.

• Between the middle and inferior constrictor muscles, the internal laryngeal nerve and the superior laryngeal artery and vein pass to the larynx.

• Inferior to the inferior constrictor muscles, the recurrent laryngeal nerve and inferior laryngeal artery pass superiorly into the larynx.

•     Part of the axial skeleton; strong, flexible rod
      Supports the head
      Gives base to the ribs
      Encloses the spinal cord
      
  o    Vertebrae
      Consists of 34 bones composing the spinal column
  •    Cervical-7 bones
  •    Thoracic-12 bones
  •    Lumbar-5 bones
  •    Sacral- 5 bones.
  •    Coccygeal-4 to 5 bones

      In the adult the vertebrae of the sacral and coccygeal regions are united into two bones, the sacrum and me coccyx
      
  o    Curvatures-from a lateraI view there are four curves, alternately convex and concave ventrally
      Two convex curves are the cervical and lumbar
      Two concave curves are the thoracic and sacral

  o    Vertebra morphology

      Each vertebra differs in size and shape hut has similar components
      Body-central mass of bone
  •    Weight bearing
  •    Fonns anterior part of the vertebra
  •    Encloses the vertebral foramen
      Pedicles of the arch-two thick columns that extend backward from the body to meet with the laminae of the neural arch 

•     Process (7)
  •    One spinous, two transverse, two superior articular, and two inferior articular
  o    Spinous process extends backward from the point of the union of thetwo laminae
  o    Transverse processes project laterally at either side from the junction of the lamina and the pedicle
  o    Articular processes arise near the junction of the pedicle and the lamina- superior processes project upward:inferior processes project downward
  •    Surfaces of the processes are smooth

  o    Inferior articular processes of the vertebra fit into the superior articular processes below
  o    Form true joints, but the contacts established serve to restrict movement

  Distinguishing features

  Cervical region- triangular shape

  •    All have foramina in the transverse process upper six transmit the vertebral artery
  •    Spinous processes are short
      o    C3 to C5 are bifurcated
      o    C7 is long-prominence felt at the back of the neck
  •    Have small bodies (except for C1 vertebra)
  •    C1 vertebra (atlas)
  o    No body
  o    Anterior and posterior arch and two lateral masses
  o    Superiorarticular processes articulate with the condyles of the occipital bone
  •    C2 vertebra (axis)-process on the upper surface of the body (dens) forms a pivot about which the axis rotates

  Thoracic region

  •    Presence of facets for articulation with the ribs (distinguishing feature)
  •    Processes are larger and heavier than those of the cervical region
  •    Spinous process is directed downward at a sharp angle
  •    Circular vertebral foramen

   Lumbar region
   
  •    Large and heavy bodies
  •    Four transverse lines separate the bodies of the vertebrae on the pelvic surface
  •    Triangular shape-fitted between the  halves of the pelvis
  •    Four pairs of dorsal sacral foramina communicate with four pairs of pelvic sacral foramina

  Sacral vertebrae 
  •    Five (sometimes six) vertebrae are fused in the adult to form the sacrum
  •    The sacrum articulates above with L5, laterally with the hip bones, and inferiorly with the coccyx.
  •    It has a roughly triangular appearance with a pelvic and dorsal surface, a lateral mass on each side, and a base and apex.
  •    An anesthetic for the spinal nerves may be injected extradurally through the sacral hiatus (caudal analgesia)
  •    The sacral canal (which contains the dura, cauda equina, and filum terminale) extends from the base to the sacral hiatus. 
  •    The apex of the sacrum may be fused with the coccyx.

  
  Coccygeal vertebrae

  •    Four to five modular pieces fused together
  •    Triangular shape with the base above and the apex below

  F Defects

  •    Lordosis-exaggerated lumbar concavity
  •    Scoliosis-lateral curvature of any region
  •    Kyphosis-exaggerated convexity in the thoracic region

->The two parietal bones (L. paries, wall) form large parts of the walls of the calvaria.
->On the outside of these smooth convex bones, there are slight elevations near the centre called parietal eminences.
->The middle of the lateral surfaces of the parietal bones is crossed by two curved lines, the superior and inferior temporal lines.
->The superior temporal line indicates an attachment of the temporal fascia; the inferior temporal line marks the superior limit of the temporalis muscle.
->The parietal bones articulate with each other in the median plane at the sagittal suture. The medial plane of the body passes through the sagittal suture.
->The inverted V-shaped suture between the parietal bones and the occipital bones is called the lambdoid suture because of its resemblance to the letter lambda in the Greek alphabet.
->The point where the parietal and occipital bones join is a useful reference point called the lambda. It can be felt as a depression in some people.
->In addition to articulation with each other and the frontal and occipital bones, the parietal bones articulate with the temporal bones and the greater wings of the sphenoid bone.
->In foetal and infant skulls, the bones of the calvaria are separated by dense connective tissue membranes at sutures.
->The large fibrous area where several sutures meet are called fonticuli or fontanelles.
->The softness of these bones and looseness of their connections at these sutures enable the calvaria to undergo changes of shape during birth called molding. Within a day or so after birth, the shape of the infant’s calvaria returns to normal.
->The loose construction of the new-born calvaria also allows the skull to enlarge and undergo remodelling during infancy and childhood.

->Relationships between the various bones are constantly changing during the active growth period.
->The increase in the size of the cranium is greatest during the first 2 years, the period of most rapid postnatal growth of the brain.
->The cranium normally increases in capacity until about 15 or 16 years of age; thereafter the cranium usually increases only slightly in size as its bones thicken for 3 to 4 years.

Intramembranous ossification

• Flat bones develop in this way (bones of the skull)
• This type of bone development takes place in mesenchymal tissue
• Mesenchymal cells condense to form a primary ossification centre (blastema)
• Some of the condensed mesenchymal cells change to osteoprogenitor cells
• Osteoprogenitor cells change into osteoblasts which start to deposit bone
• As the osteoblasts deposit bone some of them become trapped in lacunae in the bone and then change into osteocytes
• Osteoblasts lie on the surface of the newly formed bone
• As more and more bone is deposited more and more osteocytes are formed from mesenchymal cells
• The bone that is formed is called a spicule
• This process takes place in many places simultaneously
• The spicules fuse to form trabeculae
• Blood vessels grow into the spaces between the trabeculae
• Mesenchymal cells in the spaces give rise to hemopoetic tissue
• This type of bone development forms the first phase in endochondral development
• It is also responsible for the growth of short bones and the thickening of long bones