NEET MDS Lessons
Anatomy
Intramembranous ossification
- Flat bones develop in this way (bones of the skull)
- This type of bone development takes place in mesenchymal tissue
- Mesenchymal cells condense to form a primary ossification centre (blastema)
- Some of the condensed mesenchymal cells change to osteoprogenitor cells
- Osteoprogenitor cells change into osteoblasts which start to deposit bone
- As the osteoblasts deposit bone some of them become trapped in lacunae in the bone and then change into osteocytes
- Osteoblasts lie on the surface of the newly formed bone
- As more and more bone is deposited more and more osteocytes are formed from mesenchymal cells
- The bone that is formed is called a spicule
- This process takes place in many places simultaneously
- The spicules fuse to form trabeculae
- Blood vessels grow into the spaces between the trabeculae
- Mesenchymal cells in the spaces give rise to hemopoetic tissue
- This type of bone development forms the first phase in endochondral development
- It is also responsible for the growth of short bones and the thickening of long bones
Extrinsic Muscles of the Tongue (p. 746)
The Genioglossus Muscle
- This is a bulky, fan-shaped muscle that contributes to most of the bulk of the tongue.
- It arises from a short tendon from the genial tubercle (mental spine) of the mandible.
- It fans out as it enters the tongue inferiorly and its fibres attach to the entire dorsum of the tongue.
- Its most inferior fibres insert into the body of the hyoid bone.
- The genioglossus muscle depresses the tongue and its posterior part protrudes it.
The Hyoglossus Muscle
- This is a thin, quadrilateral muscle.
- It arises from the body and greater horn of the hyoid bone and passes superoanteriorly to insert into the side and inferior aspect of the tongue.
- It depresses the tongue, pulling its sides inferiorly; it also aids in retrusion of the tongue.
The Styloglossus Muscle
- This small, short muscle arises from the anterior border of the styloid process near its tip and from the stylohyoid ligament.
- It passes inferoanteriorly to insert into the side and inferior aspect of the tongue.
- The styloglossus retrudes the tongue and curls its sides to create a trough during swallowing.
The Palatoglossus Muscle
- Superior attachment: palatine aponeurosis.
- Inferior attachment: side of tongue.
- Innervation: cranial part of accessory nerve (CN XI) through the pharyngeal branch of vagus (CN X) via the pharyngeal plexus.
- This muscle, covered by mucous membrane, forms the palatoglossal arch.
- The palatoglossus elevates the posterior part of the tongue and draws the soft palate inferiorly onto the tongue.
Classification
Epitheliums can be classified on appearance or on function
Classification based on appearance
- Simple - one layer of cells
- Pseudostratified - looks like more than one layer but is not
- Stratified - more than one layer of cells
Simple epitheliums
Simple squamous epithelium
Cells are flat with bulging or flat nuclei. Lines the insides of lung alveoli and certain ducts in the kidney
Forms serous membranes called mesothelium that line cavities like: pericardial , peritoneal, plural
Lines blood vessels - known as endothelium
Simple cuboidal epithelium
It appears square in cross section, Found in: - Ducts of salivary glands, Follicles of the thyroid gland, Pigment layer in the eye, Collecting ducts of the kidney, In the middle ear is ciliated type.
Simple columnar
- Lines the gastrointestinal tract from the stomach to the anal canal, Some columnar cells have a secretory function – stomach, peg cells in the oviduct, Some columnar cells have microvilli on their free border (striated border) – gall bladder, duodenum
- Microvilli increase the surface area for absorption
- Some columnar cells have cilia – oviduct, smaller bronchi
- Cilia transport particles
Pseudostratified
Appears as stratified epithelium but all cells are in contact with the basement membrane. Has a thick basement membrane. Different cell types make up this epithelium, Cells that can be found in this type of epithelium are:
- Columnar cells with cilia or microvilli.
- Basal cells that do not reach the surface.
- Goblet cells that secrete mucous.
- Found in the trachea, epididymus, ductus deferens and female urethra
Stratified epithelium
Classified according to the shape of the surface cells
Stratified squamous epithelium
Has a basal layer that varies from cuboidal to columnar cells that divide to form new cells. Two types are found:
Keratinized: Mostly forms a dry covering, The middle layers consists of cells that are forming- and filling up with keratin. The superficial cells form a tough non living layer of keratin, Keratin is a type of protein, The skin is of this type has thick skin - found on the hand palms and soles of the feet, thin skin - found on the rest of the body
Non-keratinized: Top layer of cells are living cells with nuclei Forms a wet covering, The middle layers are polyhedral, The surface layer consists of flat squamous cells
- Is found in: mouth, oesophagus, vagina
Stratified cuboidal epithelium
Found: - in the ducts of sweat glands
Stratified columnar epithelium
Found at the back of the eyelid (conjunctiva)
Transitional epithelium
- Sometimes the surface cells are squamous, sometimes cuboidal and sometimes columnar
- The superficial cells are called umbrella cells because they can open and close like umbrellas, when the epithelium stretch and shrink
- Umbrella cells can have 2 nuclei
- Found in the bladder and ureter
Nerves of the Face
Innervation of the Muscles of Facial Expression
The Facial Nerve (CN VII)
- The seventh cranial nerve supplies the superficial muscle of the neck (platysma), the muscles of facial expression, the auricular muscles and the scalp muscles.
- CN VII is the sole motor supply to the muscles of facial expression.
- The facial nerve emerges from the skull though the stylomastoid foramen.
- Almost immediately, it enters the parotid gland. It runs superficially in this gland before giving rise to its five terminal branches: temporal, zygomatic, buccal, marginal mandibular, and cervical.
- These nerve emerge from the superior, anterior and inferior margins of the gland and spread out like the abducted digits of the hand to supply the muscles of facial expression.
- The temporal branches of CN VII cross the zygomatic arch to supply all the superficial facial muscles superior to it, including the orbital and forehead muscles.
- The zygomatic branch of CN VII passes transversely over the zygomatic bone to supply the muscles in the zygomatic, orbital and infraorbital regions.
- The buccal branches of CN VII pass horizontally, external to the masseter muscle, to supply the buccinator and the muscles of the upper lip.
- The marginal mandibular branch of CN VII supplies the muscles of the lower lip and chin.
- The cervical branch of CN VII supplies the platysma and the superficial muscles of the neck.
First pouch |
Auditory tube, which comes in contact with epithelial line of first pharyngeal cleft, where future external acoustic meatus will form. Distal portion will form tympanic cavity (lining will become eardrum) Proximal portion will become auditory tube |
Second pouch |
Forms buds that penetrate surrounding mesenchyme, which together form the palatine tonsils |
Third pouch |
Forms thymus and inferior parathyroid glands |
Fourth pouch |
Forms superior parathyroid glands |
Fifth pouch |
Forms utlimobranchial body |
Mesodermal Origin |
Muscles |
Innervation |
Somitomeres 1, 2 |
Superior, medial and ventral recti |
Oculomotor (III) |
Somitomere 3 |
Superior oblique |
Trochlear (IV) |
Somitomere 4 |
Jaw-closing muscles |
Trigeminal (V) |
Somitomere 5 |
Lateral rectus |
Abducens (VI) |
Somitomere 6 |
Jaw-opening and other 2nd arch muscles |
Facial (VII) |
Somitomere 7 |
Stylopharyngeus |
Glossopharyngeal (IX) |
Somites 1, 2 |
Intrinsic laryngeals |
Vagus (X) |
Somites 2-5 |
Tongue muscles |
Hypoglossal (XII) |
The Nasal Mucosa
- Mucosa lines the entire nasal cavities except for the vestibule of the nose.
- The nasal mucosa is firmly bound to the periosteum and perichondrium of the supporting structures of the nose.
- It is continuous with the adjoining cavities to which the nasal cavity communicates (e.g., the nasopharynx and paranasal sinuses).
- The inferior 2/3 of the nasal mucosa is called the respiratory area and air passing over this is warmed and moistened before it passes into the lungs.
- The superior 1/3 is called the olfactory area.
The Olfactory Area of Nasal Mucosa
- This area contains the peripheral organ of smell.
- Sniffing draws air into this area
- Olfactory receptor cells (from the olfactory nerve, CN I, are located in the mucosa of this area in the nose.
Nerves to the Respiratory Area of Nasal Mucosa
- The inferior 2/3 of the nasal mucosa are supplied chiefly by the trigeminal nerve (CN V).
- The mucous membrane of the nasal septum is supplied chiefly by the nasopalatine nerve, a branch of the maxillary nerve (CN V2).
- Its anterior portion is supplied by the anterior ethmoidal nerve (a branch of the nasociliary nerve) which is derived from the ophthalmic nerve (CN V1).
- The lateral walls of the nasal cavity are supplied by branches of the maxillary nerve (CN V2); the greater palatine nerve, and the anterior ethmoidal nerve.
Arteries of the Nasal Mucosa
- The blood supply of the mucosa of the nasal septum is derived mainly from the maxillary artery.
- The sphenopalatine artery, a branch of the maxillary, supplies most of the blood of the nasal mucosa.
- It enters by the sphenopalatine foramen and sends branches to the posterior regions of the lateral wall and to the nasal septum.
- The greater palatine artery, also a branch of the maxillary, passes through the incisive foramen to supply the nasal septum.
- The anterior and posterior ethmoidal arteries, branches of the ophthalmic artery, supply the anterosuperior part of the mucosa of the lateral wall of the nasal cavity and nasal septum.
- Three branches of the facial artery (superior labial, ascending palatine, and lateral nasal) also supply the anterior parts of the nasal mucosa.
Veins of the Nasal Mucosa
- The veins of the nasal mucosa form a venous network of plexus in the connective tissue of the nasal mucosa.
- Some of the veins open into the sphenopalatine vein and drain to the pterygoid plexus.
- Others join the facial and infraorbital veins.
- Some empty into the ophthalmic veins and drain into the cavernous sinus.