NEET MDS Lessons
Pharmacology
Phenobarbital (Luminal): for generalized tonic-clonic and partial seizures (not used for absence seizures)
Mechanism: enhances GABA inhibition (↑ open time of Cl channels in presence of GABA)
Side effects: sedation, ataxia, cognitive impairment, induction of hepatic microsomal enzymes
Rofecoxib
Inhibit prostacyclin(PGI2) in vascular endothelium , letting TXA2 act freely and promote platelet aggregation.
used in the treatment of osteoarthritis, acute pain conditions, and dysmenorrhea
Higher incidence of cardiovascular thrombotic events.
Not used due to increase risk of heart attack, stroke