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General Surgery

Neuromuscular Blockers in Cardiac Anesthesia

In  patient on β-blockers, the choice of neuromuscular blockers (NMBs) is critical due to their potential cardiovascular effects. Here’s a detailed analysis of the implications of using fentanyl and various NMBs, particularly focusing on vecuronium and its effects.

Key Points on Fentanyl and β-Blockers

  • Fentanyl:

    • Fentanyl is an opioid analgesic that can cause bradycardia due to its vagolytic activity. While it has minimal hemodynamic effects, the bradycardia it induces can be problematic, especially in patients already on β-blockers, which reduce heart rate and blood pressure.
  • β-Blockers:

    • These medications reduce heart rate and blood pressure, which can compound the bradycardic effects of fentanyl. Therefore, careful consideration must be given to the choice of additional medications that may further depress cardiac function.

Vecuronium

  • Effects:

    • Vecuronium is a non-depolarizing neuromuscular blocker that has minimal cardiovascular side effects when used alone. However, it can potentiate decreases in heart rate and cardiac index when administered after fentanyl.
    • The absence of positive chronotropic effects (unlike pancuronium) means that vecuronium does not counteract the bradycardia induced by fentanyl, leading to a higher risk of significant bradycardia and hypotension.
  • Vagal Tone:

    • Vecuronium may enhance vagal tone, further predisposing patients to bradycardia. This is particularly concerning in patients on β-blockers, as the combination can lead to compounded cardiac depression.

Comparison with Other Neuromuscular Blockers

  1. Pancuronium:

    • Vagolytic Action: Pancuronium has vagolytic properties that can help attenuate bradycardia and support blood pressure. It is often preferred in cardiac anesthesia for its more favorable hemodynamic profile compared to vecuronium.
    • Tachycardia: While it can induce tachycardia, this effect may be mitigated in patients on β-blockers, which can blunt the tachycardic response.
  2. Atracurium:

    • Histamine Release: Atracurium can release histamine, leading to hemodynamic changes such as increased heart rate and decreased blood pressure. These effects can be minimized by slow administration of small doses.
  3. Rocuronium:

    • Minimal Hemodynamic Effects: Rocuronium is generally associated with a lack of significant cardiovascular side effects, although occasional increases in heart rate have been noted.
  4. Cis-Atracurium:

    • Cardiovascular Stability: Cis-atracurium does not have cardiovascular effects and does not release histamine, making it a safer option in terms of hemodynamic stability.

Types of Head Injury

1. Extradural Hematoma (EDH)

Overview

  • Demographics: Most common in young male patients.
  • Association: Always associated with skull fractures.
  • Injured Vessel: Middle meningeal artery.
  • Common Site of Injury: Temporal bone at the pterion (the thinnest part of the skull), which overlies the middle meningeal artery.
  • Location of Hematoma: Between the bone and the dura mater.

Other Common Sites

  1. Frontal fossa
  2. Posterior fossa
  3. May occur following disruption of major dural venous sinus.

Classical Presentation

  • Initial Injury: Followed by a lucid interval where the patient may only complain of a headache.
  • Deterioration: After minutes to hours, rapid deterioration occurs, leading to:
    • Contralateral hemiparesis
    • Reduced consciousness level
    • Ipsilateral pupillary dilatation (due to herniation)

Imaging

  • CT Scan: Shows a lentiform (lens-shaped or biconvex) hyperdense lesion between the brain and skull.

Treatment

  • Surgical Intervention: Immediate surgical evacuation via craniotomy.
  • Mortality Rate: Overall mortality is 18% for all cases of EDH, but only 2% for isolated EDH.

2. Acute Subdural Hematoma (ASDH)

Overview

  • Location: Accumulates in the space between the dura and arachnoid.
  • Injury Mechanism: Associated with cortical vessel disruption and brain laceration.
  • Primary Brain Injury: Often associated with primary brain injury.

Presentation

  • Consciousness: Impaired consciousness from the time of impact.

Imaging

  • CT Scan: Appears hyperdense, with hematoma spreading diffusely and having a concavo-convex appearance.

Treatment

  • Surgical Intervention: Evacuation via craniotomy.
  • Mortality Rate: Approximately 40%.

3. Chronic Subdural Hematoma (CSDH)

Overview

  • Demographics: Most common in patients on anticoagulants and antiplatelet agents.
  • History: Often follows a minor head injury weeks to months prior.
  • Pathology: Due to the tear of bridging veins leading to ASDH, which is clinically silent. As the hematoma breaks down, it increases in volume, causing mass effect on the underlying brain.

Clinical Features

  • Symptoms may include:
    • Headache
    • Cognitive decline
    • Focal neurological deficits (FND)
    • Seizures
  • Important to exclude endocrine, hypoxic, and metabolic causes in this group.

Imaging

  • CT Scan Appearance:
    • Acute blood (0–10 days): Hyperdense
    • Subacute blood (10 days to 2 weeks): Isodense
    • Chronic (> 2 weeks): Hypodense

Treatment

  • Surgical Intervention: Bur hole evacuation rather than craniotomy.
  • Anesthesia: Elderly patients can often undergo surgery under local anesthesia, despite comorbidities.

4. Subarachnoid Hemorrhage (SAH)

Overview

  • Causes: Most commonly due to aneurysms for spontaneous SAH, but trauma is the most common cause overall.
  • Management: Conservative treatment is often employed for trauma cases.

5. Cerebral Contusions

Overview

  • Definition: Bruising of the brain tissue due to trauma.
  • Mechanism: Often occurs at the site of impact (coup) and the opposite side (contrecoup).
  • Symptoms: Can range from mild confusion to severe neurological deficits depending on the extent of the injury.

Imaging

  • CT Scan: May show areas of low attenuation (hypodense) or high attenuation (hyperdense) depending on the age of the contusion.

Treatment

  • Management: Depends on the severity and associated injuries; may require surgical intervention if there is significant mass effect.

Zygomatic Bone Reduction

When performing a reduction of the zygomatic bone, particularly in the context of maxillary arch fractures, several key checkpoints are used to assess the success of the procedure. Here’s a detailed overview of the important checkpoints for both zygomatic bone and zygomatic arch reduction.

Zygomatic Bone Reduction

  1. Alignment at the Sphenozygomatic Suture:

    • While this is considered the best checkpoint for assessing the reduction of the zygomatic bone, it may not always be the most practical or available option in certain clinical scenarios.
  2. Symmetry of the Zygomatic Arch:

    • Importance: This is the second-best checkpoint and serves multiple purposes:
      • Maintains Interzygomatic Distance: Ensures that the distance between the zygomatic bones is preserved, which is crucial for facial symmetry.
      • Maintains Facial Symmetry and Aesthetic Balance: A symmetrical zygomatic arch contributes to the overall aesthetic appearance of the face.
      • Preserves the Dome Effect: The prominence of the zygomatic arch creates a natural contour that is important for facial aesthetics.
  3. Continuity of the Infraorbital Rim:

    • A critical checkpoint indicating that the reduction is complete. The infraorbital rim should show no step-off, indicating proper alignment and continuity.
  4. Continuity at the Frontozygomatic Suture:

    • Ensures that the junction between the frontal bone and the zygomatic bone is intact and properly aligned.
  5. Continuity at the Zygomatic Buttress Region:

    • The zygomatic buttress is an important structural component that provides support and stability to the zygomatic bone.

Zygomatic Arch Reduction

  1. Click Sound:

    • The presence of a click sound during manipulation can indicate proper alignment and reduction of the zygomatic arch.
  2. Symmetry of the Arches:

    • Assessing the symmetry of the zygomatic arches on both sides of the face is crucial for ensuring that the reduction has been successful and that the facial aesthetics are preserved.

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