NEET MDS Lessons
Oral Pathology
General Features
-
Caused by mutation in DSPP gene (dentin sialophosphoprotein).
-
Teeth appear translucent or opalescent.
-
Enamel fractures easily due to poor dentin support.
-
Pulp chambers are obliterated or enlarged depending on type.
-
Also called Hereditary Opalescent Dentin or Shell Teeth.
Type II DI
-
Pulp chambers are normal but rapidly obliterate.
-
Associated with progressive hearing loss.
Type III DI
-
Pulp chambers are large and shell-like.
-
Seen in Brandywine isolate population.
- Mosaic / Cotton Wool Bone → Paget’s Disease
- Orange Peel / Ground Glass → Monostotic Fibrous Dysplasia
- Salt & Pepper Bone → Thalassemia
- Phantom Bone / Massive Osteolysis → Bone disappearance
- Drill / Rider’s / Exercise Bone → Myositis Ossificans
- Brittle Bone → Osteogenesis Imperfecta
- Wormian Bones → Cleidocranial Dysplasia
- Coarse Woven Bone → Fibrous Dysplasia
Benign Lymphoepithelial Lesion / Mikulicz Syndrome
-
Chronic enlargement of lacrimal and salivary glands
-
Associated with Sjogren’s syndrome
Sialosis / Sialadenosis
-
Non-inflammatory, non-neoplastic enlargement of salivary glands
Sialadenitis
-
Inflammatory disease of salivary glands
Sialadenoma Papilliferum
-
Papillomas of salivary gland excretory ducts
Atresia
-
Congenital absence or occlusion of major salivary gland ducts
Sialorrhea
-
Increased salivation
-
Seen in conditions like Parkinson’s disease
Sialolithiasis
-
Salivary duct stones in glands or ducts
-
Common in submandibular gland
Sialodochitis
-
Inflammation of salivary gland ducts
Smoker's Palate & Melanosis
- Status: NOT premalignant
- Exception: Reverse smoking palatal changes ARE premalignant
Oral Submucous Fibrosis (OSMF)
Initial Stage:
- Vesicles may be present
- Dilated capillaries
Advanced Stage:
- Compressed capillaries due to fibrosis
Non-epithelial cysts (not true cysts)
Solitary bone cyst
Radiology
The solitary bone cyst appears as a well-defined but non-corticated radiolucency. Typically, it has little effect
on adjacent structures and 'arches' up between the roots of teeth .
The inferior dental canal may not be displaced, but the cortical margins of the canal may be lost where it overlies the lesion. Expansion is rare.
Pathology
The cyst is lined by fibrovascular tissue that often includes haemosiderin and multinucleate giant cells.
Aneurysmal bone cyst
Radiology
The aneurysmal bone cyst typically presents as a fairly well-defined radiolucency. Sometimes it has a multilocular appearance because of the occurrence of internal bony septa and opacification. Marked expansion is a feature.
Pathology
The predominant feature of an aneurysmal bone cyst is the presence of blood-filled spaces of variable size lying in a stroma rich in fibroblasts, multinucleate giant cells and haemosiderin. Deposits of osteoid are also seen
Leukoplakia
- Type: Clinical term
- Histology: Hyperkeratosis ± Dysplasia
Verrucous Carcinoma
- Type: Variant of SCC
- Features:
- Intact basement membrane
- Parakeratin plugging
- Broad "elephant-foot" rete ridges
Adenosquamous Carcinoma
- Features: Mixed adenocarcinoma + SCC
- Nasopalatine cyst is the most common non-odontogenic cyst
- Globulomaxillary cyst entity is controversial - many consider it a variant of lateral periodontal cyst
- Median mandibular cyst is extremely rare - always consider other diagnoses first
- Nasolabial cyst is the only one with no radiographic features
- All these cysts are developmental in origin
Quick Facts for MCQs:
- Oval + Maxillary midline = Nasopalatine cyst
- Pear-shaped + Between teeth = Globulomaxillary cyst
- Soft tissue swelling + No X-ray changes = Nasolabial cyst
- Mandibular midline + Rare = Median mandibular cyst
MEMORY AIDS
"NASAL" for Nasopalatine Cyst:
- Non-odontogenic (most common)
- Anterior maxilla
- Spacing of centrals
- Above/between central incisors
- Location: incisive canal
"PEAR" for Globulomaxillary:
- Pear-shaped (inverted)
- Enlarges slowly
- Adjacent to lateral incisor & canine
- Root divergence
"SOFT" for Nasolabial:
- Soft tissue cyst
- Obstruction of nose
- Fold involvement (nasolabial)
- Tissue only (no bone involvement)