NEET MDS Lessons
Radiology
Radiation Biology
-X- and g -rays are called sparsely ionizing because along the tracks of the electrons set in motion, primary ionizing events are well separated in space.
Alpha-particles and neutrons are densely ionizing because the tracks consist of dense columns of ionization.
X-rays, gamma rays, electrons, and protons are all low LET forms of radiation in that their density of ionization is sparse. In general, they penetrate tissues deeply and result in less intracellular radiation injury.
High LET forms of radiation, such as heavy nuclear particles (e.g. fast neutrons), penetrate tissues less deeply and cause more radiation injury to biologic material.
Cells are most sensitive to Radiation when:
- they are undifferentiated.
Exceptions to this Law:
- lymphocyte
- Oocyte
X-rays and gamma rays show latent injury that is residual tissue damage even after the initial radiation reaction is subsided.
Proteins tend to be more radiosensitive than carbohydrates and lipids.
Most radiosensitive tissue-small lymphocyte
Most radioresistant tissue- brain
Embryonic, immature or poorly differentiated tissues are more easily injured by radiation, but they also show greater recovery properties.
All cells show increased susceptibility to radiation at the time of mitotic division and if the cells are irradiated during the resting phase, mitosis is delayed or inhibited.
- In general, cells are most radiosensitive in late M and G2 phases and most resistant in late S.
- for cells with a longer cell cycle time and a significantly long G1 phase, there is a second peak of resistance late in G1
- the pattern of resistance and sensitivity correlates with the level of sulfhydryl compounds in the cell. Sulfhydryls are natural radioprotectors and tend to be at their highest levels in S and at their lowest near mitosis.
- To produce its effect. Oxygen must be present during the radiation exposure or at least during the lifetime of the free radicals (10-5 sec).
- Mandible is more ssceptible to radiation injury than maxilla due to the denser structure and poorer blood supply.
- Salivary glands though an organ with a low turnover rate, was unusually sensitive to radiation
- Liposarcoma tumors are the most radiosensitive soft tissue tumors
- Exophytic tumors are usually more easily controlled with radiation while infiltrative and ulcerative lesions are more radioresistant.
The infiltrative and ulcerative lesions are more likely to be larger than clinically apparent and contain a larger proportion of hypoxic cells.
DENTAL X-RAY TUBE
The dental X-ray tube is surrounded by a glass envelope that houses a vacuum.
The glass prevents low-grade radiation from escaping. The vacuum insures the protection of the equipment from catastrophic failure. Production of X-rays generates enormous amounts of heat; the vacuum prevents the risk of combustion and ensures the proper environment for conduction of electrons.
There are two separate energy sources, one that powers the energy potential between the cathode ?lament and the anode, and the other being
the controls for the cathode ?lament. The latter essentially is the on and off switch of the X-ray unit.
The cathode ?lament is heated which causes electrons to be emitted.
These electrons are then accelerated by the electrical potential of the circuit.
Between the two points is a tungsten target.
When electrons strike the target, X-rays are produced.
HALF-VALUE LAYER
- Property of a material whereas the thickness (mm) reduces 50% of a monochromatic X-ray beam.
- Half-value layer of a beam of radiation from an X-ray unit is about 2 mm of aluminum (Al).
PRIMARY RADIATION
- Is the main beam produced from the X-ray tube.
SECONDARY RADIATION
- Produced by the collision of the main beam with matter which causes scatter.