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NEET MDS Quiz - Practice Test
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Practice Test

pharmacology - 3 Questions

1
Pharmacology

Alkalinization of urine is done during administration of which of the following chemotherapeutic drugs? 

1) Ara-C (Cytarabine) 
2) Methotrexate 
3) Cisplatin 
4) Ifosfamide

📝 Explanation:

Alkalinization of urine is used in patients receiving high dose methotrexate to promote renal excretion and to avoid nephrotoxicity

IV Sodium bicarbonate is used to maintain urine pH above 7.0 to avoid precipitation of methotrexate (a weak acid) in the acid pH of renal tubules

2
Pharmacology

Syncope may be treated with any of the following drug except

1)  Phenylephrine
2)  Oxygen
3)  Ephedrine
4)  Isoproterenol

📝 Explanation:

Isoproterenol is used in the management of bronchospasm during anesthesia;

adjunctive treatment for shock.

3
Pharmacology

Which of the following statements is true regarding the phase III clinical trial of a drug?

1)  It is intended to determine drug efficacy and toxicity on a large number of patients
2)  It is performed only on primates
3)  It is performed with only a few volunteer subjects
4)  It is primarily intended to determine the LD50 of a drug

📝 Explanation:

Phase III studies are randomized controlled multicenter trials on large patient groups (300–3,000 or more depending upon the disease/medical condition studied) and are aimed at being the definitive assessment of how effective the drug is, in comparison with current 'gold standard' treatment.

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