NEET MDS Quiz - Practice Test

1

Pathology

Lines of Zahn, seen grossly and microscopically in a thrombus, help distinguish:
1) Arterial from venous thrombi
2) Antemortem thrombosis from postmortem clot
3) Red infarct from white infarct
4) Fresh from organized thrombus

Option 1

Option 2

Option 3

Option 4

📝 Explanation:

Correct answer: B) Lines of Zahn are alternating pale platelet/fibrin layers and darker RBC-rich layers, forming only in flowing blood. Their presence indicates thrombosis occurred while blood was flowing (antemortem), distinguishing it from the bland, nonlaminated clots that form after death.

2

Pathology

Oral hairy leukoplakia is associated with:
1) EBV in immunosuppressed
2) HPV
3) Candida
4) HIV directly

Option 1

Option 2

Option 3

Option 4

📝 Explanation:

Oral hairy leukoplakia = EBV-driven hyperplasia of lateral border of tongue in HIV patients, non-scrapable white lesion, EBV replication in epithelium.

3

Pathology

The most common CFTR mutation causing cystic fibrosis is:
1) ?F508 (deletion of phenylalanine at codon 508)
2) G551D
3) W1282X
4) R117H

Option 1

Option 2

Option 3

Option 4

📝 Explanation:

Correct answer: 1) ?F508 is the most common CFTR mutation worldwide (especially in Caucasians), causing a misfolded protein that is degraded before reaching the cell membrane � a Class II (protein processing) defect, the most severe functional category.

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