What is the main function of the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle?
1) To reabsorb sodium and chloride
2) To reabsorb sodium and potassium
3) To reabsorb sodium and secrete hydrogen
4) To reabsorb sodium, potassium, and chloride
E) To reabsorb sodium and hydrogen carbonate
📝 Explanation:
The sodium-potassium-2-chloride (Na+-K+-2Cl-) cotransporter in the thick ascending limb of the loop of Henle is responsible for reabsorbing sodium and chloride ions from the tubular fluid into the blood. This process helps in the maintenance of osmotic balance and the generation of the medullary interstitial gradient.